My standard procedure for reel tilts is to isolate the issue. First I move reels around to see if the reel tilt moves with the bad reel. If it does, then bad reel. If it doesn't then I would check to make sure the reel is not rubbing against something while it spins. Then I check on the harness for that reel to make sure there were no bad contacts. If all the wires check out ok, then mpu is next, and then finally motherboard (though this is super rare). So to answer your question, I would try a known working MPU board. It's good to have a spare anyway.