It will work on an s6000 - it's just not supported. You have to get the manual and setup the machine properly. It's the same settings as an s2000. Here's the rub - nothing is in English on the s6000 - it's all hex codes that have to be converted.
So if you are an avid home enthusiast with some time to spend she will boot up and work. I was going to do it and even have connector where the tito plugs into the backplane. But, I never got around to it and sold the machine.
Remember, she's an old girl and you also have to make sure the bill validator is setup (or able to) take tickets.