Doc,
First, I would verify that settings are programmed under 7.1.1.3 and the pad assignments under 7.1.1.4 . If you have denominations programmed for each of the buttons, and the assignments are enabled, then you may want to try adjusting the panel slightly. However, I have found that this can create more problems if your not cautious. The removal of the board sometimes does not want to re-seat very well due to the adhesive on the back of the denom sticker. My suggestion is to have some spare of those around (if you don't already).
On my machine, my "button #2" will only activate if I use my thumb. A simple finger touch doesn't seem to work.
If you have verified all of the settings, the next thing I would consider replacing the touch panel.
-Eric